major microRNA paper

Biology News has the scoop on a major microRNA paper, out this week in Nature Genetics:

The paper, published in the latest issue of the journal Nature Genetics, found that a microRNA gene regulates, on average, 200 different human gene transcripts and that many microRNAs can coordinate their activities to regulate specific target genes. The paper contains detailed genome-wide predictions for all human microRNAs as well as tissue-specific predictions. Several predictions were validated experimentally. The findings demonstrate an unforeseen staggering complexity of gene regulation executed by microRNAs on a genome-wide level.

My gradual school advisor, Roy Parker, has been going on about this scenario for at least the last 10 years; probably longer. Looks like he was mostly right…